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12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one

Development stage: Unknown
Modality: Small Molecules

Overview

This compound is a synthetic small molecule belonging to the pyrrolocarbazole class of organic compounds and has the molecular formula C27H24N2O3 with a molecular weight of approximately 424.5 g/mol[1][5]. It is listed as an experimental drug in chemical and pharmaceutical databases but has not been approved for any medical indication or entered clinical trials as of June 2025[2][3]. Structural biology data show that it binds to mitogen‐activated protein kinase kinase kinase 9 (MAP3K9/MLK1), suggesting its mechanism involves inhibition or modulation of this kinase pathway; however detailed pharmacological characterization and therapeutic applications have not been established in public sources[6][7]. The compound is referenced by several code names (including VIN and PD004198) in structural biology and chemical probe resources.

Other names: 12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho(2,1-a)pyrrolo(3,4-c)carbazol-5(12H)-one3-(2-hydroxyethyl)-20-(propan-2-yloxy)-3,13-diazahexacyclo(14.8.0.02,10.04,9.011,15.017,22)tetracosa-1(16),2(10),4,6,8,11(15),12,17,19,21-decaen-14-one12-(2-Hydroxyethyl)-2-isopropoxy-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one

Targets

MAP3K9 (Mixed lineage kinase 1)

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